Study of 222,497 Australians suggest that sitting is deadly
The adverse effects of prolonged sitting are thought to be mainly owing to reduced metabolic and vascular health. Prolonged sitting has been shown to disrupt metabolic function, resulting in increased plasma triglyceride levels, decreased levels of high-density lipoprotein cholesterol, and decreased insulin sensitivity, which appear to be at least partially mediated by changes in lipoprotein lipase activity. It has also been suggested that sedentary behavior affects carbohydrate metabolism through changes in muscle glucose transporter protein content. Results from molecular biology and medical chemistry studies have suggested that physical activity and sedentary behavior have different influences on the body, supporting their independent effects on health. Our findings suggested not only an association between sitting and all-cause mortality that was independent of physical activity but, because the findings persisted after adjustment and stratification for BMI, one that also appears to be independent of BMI.